The UK rejoins Horizon programme, and how we lost our tails

Plus, a breakthrough in better battery building
01 March 2024
Presented by Chris Smith
Production by James Tytko, Rhys James.

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In this episode of The Naked Scientists: As the UK rejoins the EU Horizon research programme, we hear from the Secretary of State for Science, Innovation and Technology on what she sees as the benefits from this “new deal”. Also, scientists discover a way to get lithium batteries charging faster, and performing better in the cold. And how, and why, did we humans lose our tails back in history?

Michelle - Horizon isn't a EU exclusive scheme. What Horizon is, is it's the world's largest research collaboration program. So for the UK to reassociate is a big deal, not just for the scientific community and for businesses who can access it, but of course for the British public who ultimately will benefit from any developments in research. That could include drug discovery or medical advances or climate change. So this is really good news and what makes this different is the fact that this is a better deal than what we had on the table when we first left the European Union. We have the ability to be able to obtain more money than we're putting in by the nature of it. And we also have a safety mechanism. So if the reverse happens, we're protected and we can get some money back. So this is good news for the taxpayer as well. And on average, each business in the UK will benefit £450,000. So they bid in for a pot of money to help them in terms of a research and development project. And then they are accessing this research collaboration fund.

Chris - But how much is this costing us to be in the club in Europe? Because when we left the Horizon program, the UK government, because the UK is a big contributor to science anyway, said, 'well actually, we'll just step in and fill the void of what the grants coming back from the Horizon program would've been.' So it was sort of cost neutral at the time to UK science apparently. But what's it costing now and why are the EU even interested in signing up to this if we get more back than we were putting in before?

Michelle - So basically to bridge the gap, we did something called the Horizon guarantee. So we didn't leave scientists and innovators and businesses without any potential funding during that period of time, but this will be costing us roughly £2 billion a year. But it depends on how much we're actually getting back. And that's why we want to maximise this opportunity. So when I talked to scientists and businesses and innovators, and when I began in this role, their key message to me was, we have to associate with Horizon because of the value that that will add. When we were previously members, over half of the projects that we were involved with, we led on. So we've got a legacy of being very successful in this scheme. We want to maximise this opportunity to get the most value for money out of it for the taxpayer. So we've not just been hoping that businesses and scientists bid into it. We've actually been marketing our rear association, especially to those that are new to academia, younger scientists and researchers and to businesses that haven't participated before. We've also been giving funds to help with the process of bidding in. And in addition, we've got a road show that's already beginning. First one is partnering with the University of Birmingham to raise real awareness about our association and to provide some of the answers to how does this actually work? How do I access this fund if I want to participate? And we've also worked with Innovate UK, which is an arm of UKRI, which is basically the big body that gives out research funding in the UK. And they have redesigned the website and the processes to make this as simple as quick and as easy as possible for those who want to participate in the scheme.

Chris - Allied to that is something which is really important at the moment worldwide, which is this pursuit of net zero and better ways of generating the energy we need in future. Correct me if I'm wrong though, we're out of the European fusion endeavours though, aren't we? We've been a big contributor to ITER, which is the experimental nuclear reactor at Cadarache in France, a big fusion project. We're not part of that now through this deal.

Michelle - So there were three schemes under basically one umbrella often in terms of how they were referred to. And they are Horizon, which we've been talking about here today, Copernicus, which we've also reassociated with, and Euratom. Now, we didn't decide to reassociate with Euratom because we've been listening to the experts, those on the ground that actually benefit from these schemes, who spent a great deal of time talking to that sector who made it very, very clear that given the gap in time of association, that it would be far better for the British fusion sector to get that same quantum in money, but get it directly to them rather than go round the scheme.

Chris - So you are going to do that. You're actually pursuing a UK fusion sector?

Michelle - We are giving the same quantum of money, but directly to the UK sector. And that was the direct ask of the fusion sector in this country.

Chris - Got to be careful with the word quantum though, because it means something very, very small

Michelle - But it's the same volume of money that we had <laugh> or even giving. I think we, we can play around with different words, but I can assure you they all mean the same thing when they're coming out of my mouth, which is that we have been very clear that the money that we would've put in to Euratom is the same money that the sector will be getting, but rather than going via a middleman if you like. They're getting it directly, which was their ask and it was the ask of their association body. And we listen to that.

Chris - Where does the government stand on net zero climate change now?

Michelle - Well, we haven't deviated in our position of saying how important it is that we tackle climate change and that we stick to our 2050 target. We were the first country in the world to legislate, to put that on the statute books. What we did change last year was some of the ways in which we get there by delaying some of the targets and making them more doable. There's no point setting targets for target's sake if we all know that they're not achievable or that they'll bankrupt the nation or that they're impossible for normal families, including families in my constituency. We have to be realistic about these things. And I think that the thing that the Prime Minister said that really resonated with me was that what we were in danger of doing if we stood blindly to those targets, was alienating people away from something that is incredibly important. And I believe passionately that we all have a role in tackling climate change, not just governments, not just local councils, not just local communities, but on an individual basis. And to be able to achieve that, everybody's got to buy into that mission. And we actively need to be turning people towards that, not against it. And therefore it has to be realistic. It has to be affordable. But we certainly haven't deviated in any way from the end goal. Not at all.

Chris - Are you planning, though, to try and tighten up and close the gap on how we actually account for emissions? Because for instance, if we shut down an industry in this country and buy what we would've made here from overseas, we've basically exported the carbon emissions to someone else's country and someone else's problem. It's a global problem ultimately, but we've made it appear on their books as a carbon output. Are we actually properly accounting for these sorts of things? Another example, people are saying, let's build a solar farm, for example. But when you look at the calculations for all the farmland being replaced by solar panels, they're not taking into account the fact that the food that would've been grown there is now accruing a big carbon footprint coming from grain producing nations overseas.

Michelle - But that's not strictly true because solar is predominantly placed on low agricultural grade land that wouldn't therefore have the same propensity to go through. But the broader point is that there is merit to your, the sentiment of your argument when the fact that we are responsible for a tiny, tiny proportion of the world's carbon emissions. Therefore it is a global challenge. And that is very much why we have been trying to encourage, enable, and support the rest of the world in this mission to be able to tackle climate change. That's why we have been so forthright in our work and support of the COP process as well.

Chris - I wanted to ask you about artificial intelligence as well, because that's an area where the UK traditionally can make a big difference. And I know that the Prime Minister made some quite enthusiastic points about that. What can you tell us about what scientifically you have in mind in that direction?

Michelle - Yeah, absolutely. So artificial intelligence is the fastest moving emerging technology that I believe we've ever seen. And with that comes humongous opportunities. Some of those opportunities we are already seeing in the likes of our NHS with the detection of breast cancer quicker, with the use in nearly 90% of all stroke units, for example. It is assisting many professions and the future is really limitless in relation to artificial intelligence. But with that, the other side of the coin has very real and potential risks.They are basically two sides of the same coin. And that is very much why we have tried to address and grip those risks so that we can seize those huge opportunities in our public services and our businesses, and we can make sure that the British public draw down on the benefits of artificial intelligence. And it was this government and my department, which led the way with the first ever AI safety summit back in November in Bletchley Park where we convened the world, not just governments, but also the companies producing artificial intelligence. Those at the cutting edge of what we call the frontier of artificial intelligence and also members of civil society, academics and experts who have studied this field for a great deal of time. We produced a landmark declaration agreement, the Bletchley declaration. We also got a landmark agreement to ensure that we can test the models pre-deployment, which is vitally important because the next set of models are about to come out. And with every generation of new models, the capability increases. And we have set up the world's first ever institute to do just that, to test these models, both pre and post-deployment. A number of countries around the world have talked about this and are in the process of doing this, like America, Japan, Singapore, and France, who I have been meeting with today. But the stage that they're at with their institute is earlier than ours. We have our institute fully set up and already testing these models that is enabling us to really prioritise the safety of the British public. It's looking at things like societal harms, looking at things like loss of control and also misuse. But the only reason we're doing all of that is so that we can seize these opportunities in the likes of our NHS in our transport networks, our businesses can deploy AI and be more efficient and effective so we can add to our economic growth. So we can grow our jobs. And the other thing that we're trying to do is really foster an innovative environment so that AI companies want to locate here, they want to grow here, they want to create more jobs on British soil. And that's been working. We have already Google DeepMind as a homegrown success story in the UK, but OpenAI and Anthropic, two of the biggest AI companies have chosen the UK to locate their international headquarters. And we have a full spectrum of AI corporations right through the ecosystem at all stages with the AI industry.

In this episode

A view of Big Ben and the top of Elizabeth Tower, with Boadicea in the foreground.

The UK rejoins Horizon Research and Innovation programme
Michelle Donelan, UK Secretary of State for Science, Innovation and Technology

The UK severed ties with Europe’s £80 billion Horizon research and innovation project following its exit from the EU. The move provoked great consternation amongst large parts of the country’s scientific community at the time, and it has taken several years of painstaking negotiations for the UK to finally regain associate membership. But is the deal as good as the one that it had before Brexit? Michelle Donelan is the UK Secretary of State for Science, Innovation and Technology.

Michelle - Horizon isn't a EU exclusive scheme. What Horizon is, is it's the world's largest research collaboration program. So for the UK to reassociate is a big deal, not just for the scientific community and for businesses who can access it, but of course for the British public who ultimately will benefit from any developments in research. That could include drug discovery or medical advances or climate change. So this is really good news and what makes this different is the fact that this is a better deal than what we had on the table when we first left the European Union. We have the ability to be able to obtain more money than we're putting in by the nature of it. And we also have a safety mechanism. So if the reverse happens, we're protected and we can get some money back. So this is good news for the taxpayer as well. And on average, each business in the UK will benefit £450,000. So they bid in for a pot of money to help them in terms of a research and development project. And then they are accessing this research collaboration fund.

Chris - But how much is this costing us to be in the club in Europe? Because when we left the Horizon program, the UK government, because the UK is a big contributor to science anyway, said, 'well actually, we'll just step in and fill the void of what the grants coming back from the Horizon program would've been.' So it was sort of cost neutral at the time to UK science apparently. But what's it costing now and why are the EU even interested in signing up to this if we get more back than we were putting in before?

Michelle - So basically to bridge the gap, we did something called the Horizon guarantee. So we didn't leave scientists and innovators and businesses without any potential funding during that period of time, but this will be costing us roughly £2 billion a year. But it depends on how much we're actually getting back. And that's why we want to maximise this opportunity. So when I talked to scientists and businesses and innovators, and when I began in this role, their key message to me was, we have to associate with Horizon because of the value that that will add. When we were previously members, over half of the projects that we were involved with, we led on. So we've got a legacy of being very successful in this scheme. We want to maximise this opportunity to get the most value for money out of it for the taxpayer. So we've not just been hoping that businesses and scientists bid into it. We've actually been marketing our rear association, especially to those that are new to academia, younger scientists and researchers and to businesses that haven't participated before. We've also been giving funds to help with the process of bidding in. And in addition, we've got a road show that's already beginning. First one is partnering with the University of Birmingham to raise real awareness about our association and to provide some of the answers to how does this actually work? How do I access this fund if I want to participate? And we've also worked with Innovate UK, which is an arm of UKRI, which is basically the big body that gives out research funding in the UK. And they have redesigned the website and the processes to make this as simple as quick and as easy as possible for those who want to participate in the scheme.

Chris - Allied to that is something which is really important at the moment worldwide, which is this pursuit of net zero and better ways of generating the energy we need in future. Correct me if I'm wrong though, we're out of the European fusion endeavours though, aren't we? We've been a big contributor to ITER, which is the experimental nuclear reactor at Cadarache in France, a big fusion project. We're not part of that now through this deal.

Michelle - So there were three schemes under basically one umbrella often in terms of how they were referred to. And they are Horizon, which we've been talking about here today, Copernicus, which we've also reassociated with, and Euratom. Now, we didn't decide to reassociate with Euratom because we've been listening to the experts, those on the ground that actually benefit from these schemes, who spent a great deal of time talking to that sector who made it very, very clear that given the gap in time of association, that it would be far better for the British fusion sector to get that same quantum in money, but get it directly to them rather than go round the scheme.

Chris - So you are going to do that. You're actually pursuing a UK fusion sector?

Michelle - We are giving the same quantum of money, but directly to the UK sector. And that was the direct ask of the fusion sector in this country.

Chris - Got to be careful with the word quantum though, because it means something very, very small

Michelle - But it's the same volume of money that we had <laugh> or even giving. I think we, we can play around with different words, but I can assure you they all mean the same thing when they're coming out of my mouth, which is that we have been very clear that the money that we would've put in to Euratom is the same money that the sector will be getting, but rather than going via a middleman if you like. They're getting it directly, which was their ask and it was the ask of their association body. And we listen to that.

Chris - Where does the government stand on net zero climate change now?

Michelle - Well, we haven't deviated in our position of saying how important it is that we tackle climate change and that we stick to our 2050 target. We were the first country in the world to legislate, to put that on the statute books. What we did change last year was some of the ways in which we get there by delaying some of the targets and making them more doable. There's no point setting targets for target's sake if we all know that they're not achievable or that they'll bankrupt the nation or that they're impossible for normal families, including families in my constituency. We have to be realistic about these things. And I think that the thing that the Prime Minister said that really resonated with me was that what we were in danger of doing if we stood blindly to those targets, was alienating people away from something that is incredibly important. And I believe passionately that we all have a role in tackling climate change, not just governments, not just local councils, not just local communities, but on an individual basis. And to be able to achieve that, everybody's got to buy into that mission. And we actively need to be turning people towards that, not against it. And therefore it has to be realistic. It has to be affordable. But we certainly haven't deviated in any way from the end goal. Not at all.

Chris - Are you planning, though, to try and tighten up and close the gap on how we actually account for emissions? Because for instance, if we shut down an industry in this country and buy what we would've made here from overseas, we've basically exported the carbon emissions to someone else's country and someone else's problem. It's a global problem ultimately, but we've made it appear on their books as a carbon output. Are we actually properly accounting for these sorts of things? Another example, people are saying, let's build a solar farm, for example. But when you look at the calculations for all the farmland being replaced by solar panels, they're not taking into account the fact that the food that would've been grown there is now accruing a big carbon footprint coming from grain producing nations overseas.

Michelle - But that's not strictly true because solar is predominantly placed on low agricultural grade land that wouldn't therefore have the same propensity to go through. But the broader point is that there is merit to your, the sentiment of your argument when the fact that we are responsible for a tiny, tiny proportion of the world's carbon emissions. Therefore it is a global challenge. And that is very much why we have been trying to encourage, enable, and support the rest of the world in this mission to be able to tackle climate change. That's why we have been so forthright in our work and support of the COP process as well.

Chris - I wanted to ask you about artificial intelligence as well, because that's an area where the UK traditionally can make a big difference. And I know that the Prime Minister made some quite enthusiastic points about that. What can you tell us about what scientifically you have in mind in that direction?

Michelle - Yeah, absolutely. So artificial intelligence is the fastest moving emerging technology that I believe we've ever seen. And with that comes humongous opportunities. Some of those opportunities we are already seeing in the likes of our NHS with the detection of breast cancer quicker, with the use in nearly 90% of all stroke units, for example. It is assisting many professions and the future is really limitless in relation to artificial intelligence. But with that, the other side of the coin has very real and potential risks.They are basically two sides of the same coin. And that is very much why we have tried to address and grip those risks so that we can seize those huge opportunities in our public services and our businesses, and we can make sure that the British public draw down on the benefits of artificial intelligence. And it was this government and my department, which led the way with the first ever AI safety summit back in November in Bletchley Park where we convened the world, not just governments, but also the companies producing artificial intelligence. Those at the cutting edge of what we call the frontier of artificial intelligence and also members of civil society, academics and experts who have studied this field for a great deal of time. We produced a landmark declaration agreement, the Bletchley declaration. We also got a landmark agreement to ensure that we can test the models pre-deployment, which is vitally important because the next set of models are about to come out. And with every generation of new models, the capability increases. And we have set up the world's first ever institute to do just that, to test these models, both pre and post-deployment. A number of countries around the world have talked about this and are in the process of doing this, like America, Japan, Singapore, and France, who I have been meeting with today. But the stage that they're at with their institute is earlier than ours. We have our institute fully set up and already testing these models that is enabling us to really prioritise the safety of the British public. It's looking at things like societal harms, looking at things like loss of control and also misuse. But the only reason we're doing all of that is so that we can seize these opportunities in the likes of our NHS in our transport networks, our businesses can deploy AI and be more efficient and effective so we can add to our economic growth. So we can grow our jobs. And the other thing that we're trying to do is really foster an innovative environment so that AI companies want to locate here, they want to grow here, they want to create more jobs on British soil. And that's been working. We have already Google DeepMind as a homegrown success story in the UK, but OpenAI and Anthropic, two of the biggest AI companies have chosen the UK to locate their international headquarters. And we have a full spectrum of AI corporations right through the ecosystem at all stages with the AI industry.

An ape

The tale of how humans lost their tails
Itai Yanai, NYU Grossman School of Medicine

Humans, chimpanzees, gorillas and orangutans do not have tails. It sets us apart from other primates, but suggests that our shared evolutionary ancestors had them. So why did we lose them, and how? Itai Yanai is a geneticist and systems biologist at NYU Grossman School of Medicine, and the way this study began was literally as a pain in the arse for one of his colleagues…

Itai - The story starts with a student in my lab, his name is Bo Xia. Bo got injured while sitting in a car. So he moved over and he sat unfortunately on a belt buckle and he injured his tailbone. It all sort of culminated in a very simple question, how did we lose our tail? The chimpanzee, they don't have a tail, the gorilla doesn't have a tail. But if you go to something more distantly related like the macaque monkey, the macaque monkey of course still has a tail.

Chris - Is one way to try and find out why we even had a tail historically and how these other animals have a tail. Is it, you go and look at them and ask, well, what genes have they got that might make them have a tail? Because then you can, you can ask, well, are they different in us?

Itai - Right. So what Bo did is he studied the genome using a genome browser that allows him to see very conveniently, what does our genome look like? And particularly what does it look like when you compare it to the genomes of other animals like the macaque, like the gorilla and the chimpanzee. And what he saw is that there is a particular element that's in a region that doesn't look like it would be important. It doesn't look like it would be very disruptive. However, it had three interesting things about it. One, it was in this gene that was known for a very long time that it's responsible for the tail. Two, it's an element that we could see at the right time. Why is it at the right time? Because all the animals that have this change don't have a tail. And all the animals that do still have a tail lack this element. So it was the right pattern. And three, knowing molecular biology, Bo could see that that actually would be highly disruptive. So now Bo had a hypothesis, this change is how we lost our tail.

Chris - So in summary then you home in on this region of the DNA, which we know is linked to animals having tails or tail function. And that in animals that appear not to have a tail, there is a region of that gene which has a change in it, and it's in all the animals that don't have a tail. And it appears in such a way that it would disrupt or affect how that gene would work, which does look like a smoking gun genetically then.

Itai - Exactly. So now the question is what do you do with this? Bo and I sat down together and we designed this experiment where we would generate mice that have exactly the same kind of mutation that we saw that we have. And the prediction would be that if you make mice like that, they would also lose their own tails.

Chris - And do they? If you introduce this same change into a mouse, do you end up with mice with truncated or absent tails?

Itai - You know, they do and I still get goosebumps every time I think about it. They do. They're born without a tail. And although it took years of work, four years of generating mice and studying them, what we saw was that there's a correspondence between how much disruption we put in and the length of the tail.

Chris - Now most things that get fixed in evolution confer some kind of advantage. So on the one hand we lose a tail and gain 'taillessness'. So what would've been the advantage that would've meant this was so strongly selected for in the group of animals that were our ancestors back in history?

Itai - It was 25 million years ago, so we'll never know for sure. The way we speculated is that actually it could very well be that this mutation was the fundamental mutation that led to us sitting down here and talking on The Naked Scientists podcast that facilitated us to come down from the trees and have a life on the ground where we now stand on our two feet.

Chris - One issue though is that that part of the body, how we form the backbone and the spinal cord that overlays it, there is a small group of unfortunate people in the population who suffer neural tube defects. The condition spina bifida where the tube that forms the spinal column doesn't close up properly at one end, the tail end. Now does this link up with, or is that associated with, this particular gene and is there therefore a risk if you disrupt it that you're going to get more of that happening?

Itai - Yeah, you know, this was a completely unexpected aspect of this project that when we made the mice with those mutations, some of them were born with a condition that looked remarkably similar to the human condition that you mentioned with neural tube defects. And I think now it could lead to a series of new studies that promise to make some kind of advancements on how we treat this disease. And yet that's the magic of science, that if you let people follow their curiosity, it will lead to interesting places that are just unpredictable.

A row of double and triple A batteries.

How can we improve the performance of batteries?
Rhodri Jervis, UCL

Rechargeable lithium-ion batteries have revolutionised the modern electrical area, unlocking the door to powerful devices that we rely on each day, such as phones and electric cars. But where they fall down is in the time it takes to charge them, and how well they perform across a range of temperatures and especially in the cold. But now scientists in China have come up with a new recipe for the electrolyte that enables the lithium ions, which store the energy in these batteries, to move around. This can hugely increase the rate at which the battery is able to charge and discharge, and it does it even in the very cold. Rhodri Jervis works on ways to build better batteries at UCL.

Rhodri - All batteries, all electrochemical devices have to have three main things. Those are electrodes whereby the electron transfer happens, the electricity is transported, and they will have a positive and negative electrode. They will have an electrolyte, which is some sort of salt dissolved in some sort of liquid, which we call the solvent. And they will have a separator to keep those two electrodes apart and to allow the electrolyte to transfer between them. So if you opened up, and we do this in the lab in a very safe way obviously, but if you were to open up a lithium ion battery, you would see a couple of very thin foils, copper and aluminium foils, onto which these electrodes are actually printed. So the electrodes in lithium ion batteries are composed of particles of what we call active material, this is the material that can charge and discharge and there'd be a positive and negative electrode of these sort of coated foils. They look just like black inks, basically like dried black inks. And then in between those electrodes you would have this liquid solution of salt dissolved in the solvent. And that's the key thing that they've changed in this paper to allow for the charging of the battery to be much faster.

Chris - There are some constraints with the present generation of lithium batteries. I mean, they're brilliant and they've transformed industry as well as life in general, haven't they? But those constraints are - they don't work very well in the cold as my electric car keeps telling me, and they tend to, as my mobile phone is increasingly telling me, degrade with time, they don't hold as much charge, they don't work as well. Why does that happen? Before we get into what the new study shows, why do I see those changes in battery performance?

Rhodri - Yeah, it's a very good question. It's one that we're trying to solve all the time. Just to sort of take it back to the usefulness of lithium ion batteries, you're absolutely right. They have been transformative over the past 30 or 40 years since they've been around. And one of the key innovations in the commercialisation of these batteries by Sony was to use graphite as the negative electrode instead of lithium metal, which is what people used previously. This lithium metal wouldn't charge and discharge, wouldn't cycle very repeatedly, and also caused some safety issues as well. So the use of graphite was really key in making reliable safe batteries. However, that is what actually limits the rate at which the batteries can charge. When the graphite accepts lithium charged particles during that charging process, it can actually degrade a little bit of the electrolyte, that liquid that sits within the battery. And it could end up causing this very thin coating on the, on the surface of the graphite. We call this an SEI, it doesn't really matter what that means, but it's basically a very thin coating. This actually helps to protect the graphite causing any further breakdown of that electrolyte. So this SEI is a really key thing to the stable operation of these lithium ion batteries. However, that last journey for the lithium charge particle has to go through that thin SEI layer and that sort of dictates how quickly those lithium particles can move through the battery, which of course then dictates how quickly you can charge your car. So at the moment you'd be limited to maybe half an hour, an hour probably of charging over time. One of the degradation modes is for that SEI layer to thicken and therefore increase the resistance that the lithium particles feel when they travel through that. The materials can crack, we can have gas evolution. There's all sorts of ways in which lithium ion batteries slowly degrade. They are pretty remarkable in how long they last currently, but one of the key things we're trying to unlock is this fast charging ability. If you could charge your car in 10 minutes, that very much changes how you approach a long journey, how you approach range anxiety, and also probably the size of the battery pack that you want in your car. So currently people have very large battery packs so that they don't need to charge as much, because it takes at least half an hour to charge. So if you cut that down to five or 10 minutes, perhaps it's less of an issue.

Chris - Which of the problems have they addressed in this paper or both?

Rhodri - They've addressed a couple of different problems here. So the fundamental problem of the rate at which these charged lithium particles move through the electrolyte has improved. So when these lithium ions, these lithium particles, are dissolved in the electrolyte, they're surrounded by the other constituents of that electrolyte. And these serve to sort of slow down the movement of this lithium particle through the electrolyte. You can kind of think of it as someone trying to get through a crowded room at a party. If that person's very popular and everyone wants to stop and talk to them for a few minutes, that's going to take a long time for them to get from one side of the room to the other. But there are other mechanisms by which this lithium can travel through the electrolyte and one is by sort of hopping across a linked region of lots and lots of lithiums. So if you have a high concentration of these things, it's almost like passing a note amongst other people. And that's sort of what they've done here. They've created a network via which these lithium particles can travel very quickly, but they've also made a new type of solvent that allows for a formation of this SEI layer that I mentioned, this protective layer that allows for very rapid transport of lithium through that last little bit of its journey. So through the work in this paper, they've managed to even at very low temperatures of sort of minus 70 degrees, about as low as you'd ever <laugh> want to drive around in really, they've managed to allow for charging rates that would be the equivalent of charging your car at 10 minutes or less, which is really quite remarkable.

Chris - Is it practical though? Because there are things we can do which would work wonderfully, but they would be completely economically viable or toxic as you like. Are these materials that they're talking about invoking to do this environmentally friendly and sustainable and more moreover cheap?

Rhodri - That is a key issue. So currently lithium ion batteries employ what we would call organic solvents instead of for example, water, which would be very sustainable. And a lot of these things are not sustainable and they're actually quite flammable. This solvent is different to the organic solvents that are used currently, but it is still an organic material. So I'm not entirely sure of how sustainable this would be compared to the current materials, but one thing is that it would allow a much better performance and potentially than with the fast charging smaller battery packs. And one of the best things you can do for sustainability with batteries is use fewer batteries. In that respect, it should be very positive.

Orchestra

Live music strikes a chord between listener and performer
Sascha Fruehholz, University of Zurich

What exactly does live music do to our brains? It turns out that there’s a sort of neurological resonance between performer and listener, whereby the performers alter their playing to drive the emotional responses of the audience. This partly explains why watching your favourite band play live is so much better than listening to a studio recording. The University of Zurich’s Sascha Fruehholz, a professor in cognitive neuroscience, has been piping real-time performances to listeners inside brain scanners, and then feeding the scan results back to the players with the instruction to play in such a way to maximise the emotional response…

Sascha - There was not so much research on live music. We want to see how much more intense is live music compared to recording music. And the other dimension was the brain. And we do a lot of research on the specific part of the brain that we call the effective brain or the limbic system. And one part of the limbic system is the amygdala, which is really central to any kind of emotional processing. So we just wanted to see how the amygdala responds to live music.

Chris - I suspect that one of the reasons why there's a paucity of information about live music and the brain response is that you can't take a brain scanner to a rock concert, can you? So how did you get around that one?

Sascha - Well, this is probably, as you said, this is a limitation. So if you want to quantify brain activity, we need these big machines. So what we had in the experiments, we had people in the brain scanner. So we quantified brain activity in real time, especially again in the limbic system in the different rooms we had the musicians, piano players seeing the brain activity of the person inside the scanner so they really could follow brain activity. And we asked them, if you see that the activity in the limbic system is going down, try to change something in the performance.

Chris - Neat. So basically it's like a biofeedback thing where you turn the brain images that are coming off of the person's responses to the music they're presumably hearing while they're in the brain scan are coming from these live musicians. You present that back to the live musicians and they're playing to try to make the brain activity change in a way that does something in sync with their music. So what sorts of things did the musicians do to respond and what sorts of responses did the person's brain produce when they heard the change in the music?

Sascha - They changed what we call the timbre of the music, so the sound quality. They changed the tempo, for example, they changed the complexity of the piece and all of this in the end has been successful. So when these musicians introduce changes in the way they perform, the piece we saw increases the activity of people listening.

Chris - When you go to a live event is this what's going on? You would say that the musicians on the stage are in some way subtly changing the way they play, which is synchronised with the responses they're getting off the crowd. So the two kind of gel.

Sascha - Exactly like this, and this can only happen during live music. So you have the musicians on one side and they try to produce a performance in order to increase the emotional experience of the audience while they perform. They see the responses of the audience. And then if they, for example, see the audience is not happy, they try to introduce some changes.

Chris - What happens if you play music to somebody that they absolutely loathe? I mean there are certain musicians, certain genres of music, which I can't stand. Others I absolutely love <laugh>. Did you try any of that to see whether music that one person loves activates a totally different set of circuits when they're loving it compared to someone who's loathing it?

Sascha - That's actually an interesting question actually. And we know the amygdala being part of the limbic system or the emotion brain responds to both something you like, but also if you listen to something that you completely hate in terms of music. In our study on music and the emotional reaction listeners, we had positive music. So music that makes you happy, but we also had music that we called unpleasant. So it's negative music, more inducing emotions like let's say sadness or nostalgia for example. It portrays a negative emotion music. But some people still like to listen to this minor note music.

Chris - Is it like eating your greens? You know it doesn't taste great but it's good for you. And so you need that kind of contrast in the music because it kind of stretches you emotionally. Do you think that's what's going on?

Sascha - Yes. I mean music has a dimension that we call an aesthetic dimension. So it's not only the music itself, but music also like it has a theme, it has a specific topic and sometimes these topics can be negative, but still you would like to listen to this music because you're interested in this negative theme in the end.

A woman clutching hear head, with another set of arms covering her face.

Could you keep a head alive on its own?

Will - Thanks David. I’m not sure I’d want to be the first to give it a go either. But is it feasible? Could we transfer our head to a different body? Adam Taylor, Professor of Anatomy at Lancaster University, is on hand to help us out…

Adam - One of the main issues with any transplant is immune rejection: when the body recognises the tissue doesn’t belong to them. We can now manage that with anti rejection drugs so it dampens down the immune response so it enables the organ to function without the body attacking it.

Will - Thanks to immunosuppressants, transplants of organs have been going on successfully for decades: kidneys, livers and even hearts and lungs.

Adam - But when we look at the head as a whole, that’s a lot more difficult a conundrum to solve. We’re transplanting a number of organs and structures that have to be connected up to the donor. There’s a very methodical approach, we have to maintain the donor tissue alive but not alive enough that it burns through all of its energy stores.

Will - And when it comes to the head, the organ consuming most of our body’s energy is the brain, which hoovers up 20% of all the blood coming out of our hearts with every single beat.

Adam - We would have to cool the brain down, put it into a temporary hibernation, while the surgeons go about attaching the major arteries etc. 

Will - Everything we’ve discussed so far, while difficult, is nonetheless doable. But, what we haven’t yet touched on, is where the prospect of a head transplant becomes a lot less realistic…

Adam - And that comes with the issue of the spinal cord. Nerves are not great at regenerating themselves in the brain and the spinal cord. We are getting closer to that in a medical context, some interesting things are happening. The challenge is our spinal cord is segmented, full of motorways that control your movements. Connecting the body with the head so that the motorways line up properly is a big challenge. One we don’t see being solved anytime soon.

Will - There you have it, David. Keep your head up, and maybe we’ll get there some day. Thanks very much to Adam Taylor from the University of Lancaster…

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